Scientist/Senior Scientist, Medicinal Chemistry (strong chemical biology

<h3><span style="font-size: 14pt;"><strong>tl;dr</strong></span></h3> <p><span style="font-size: 10pt;">General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.</span></p> <p><span style="font-size: 10pt;">We are seeking a <a href="https://www.youtube.com/watch?v=Uyzqmn8Azuo" target="_blank">first-rate</a> <span style="color: rgb(0, 0, 0);">medicinal chemist</span>&nbsp;to help us pioneer this uncharted frontier of drug discovery.</span></p> <hr> <h3><span style="font-size: 14pt;"><strong>Our Story</strong></span></h3> <p><span style="font-size: 10pt;">A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition<a href="https://www.nature.com/articles/nrd.2016.230" target="_blank">[1]</a>, but there are many other possible perturbation types whose potential remains unrealized.</span></p> <p><span style="font-size: 10pt;">General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).</span></p> <p><span style="font-size: 10pt;">Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[<a href="https://www.nature.com/articles/nrd3410" target="_blank">2</a>, <a href="https://www.nature.com/articles/nrd.2016.213" target="_blank">3</a>, <a href="https://www.nature.com/articles/nrd.2016.211" target="_blank">4</a>], and our technology holds the same promise.</span></p> <h3>&nbsp;</h3> <h3><span style="font-size: 14pt;"><strong>The Position</strong></span></h3> <p><span style="font-size: 10pt;">We are seeking an <strong>experienced medicinal chemist with chemical biology training to be a founding member of our Chemistry/Drug Discovery Team</strong>. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.</span></p> <p><span style="font-size: 10pt;">Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing <em>in cellulo</em> assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.</span></p> <h3>&nbsp;</h3> <h3><span style="font-size: 14pt;"><strong>About You</strong></span></h3> <p><span style="font-size: 10pt;"><strong>High Agency.</strong> Initiative, independence, and self-accountability are some of our most valued traits.</span></p> <p><span style="font-size: 10pt;"><strong>Enthusiastic.</strong> We love people who are excited about what they are doing and are generally attempting to build a high-energy team.</span></p> <p><span style="font-size: 10pt;"><strong>Intensity and Grit.</strong> Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.</span></p> <p><span style="font-size: 10pt;"><strong>Prosocial.</strong> We are here to create life-saving medicines for the patients who need it most. You should be, too.</span></p> <h3>&nbsp;</h3> <h3><span style="font-size: 14pt;"><strong>Qualifications &amp; Nice-To-Haves</strong></span></h3> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;">PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Industry experience is desirable, but the ability to work hard and learn fast is more important to us.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Deep understanding of small-molecule drug discovery and its relationship to human disease.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Applicant must be able to work fluently at the interface of chemistry and biology.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Top-notch written and oral communication skills.</span></li> </ul> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;"><strong>Strong experience with:</strong></span> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Contributing to hit-to-lead and lead optimization studies</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Applicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry<br></span></li> </ul> </li> </ul> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;"><strong>Nice to have:</strong></span> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Proficiency in HTS and phenotypic assay development</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Computational or molecular dynamics drug discovery experience</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">DEL experience</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Experience managing others, especially synthetic chemistry CRO teams</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Prior experience on teams that have successfully advanced research to the clinic</span></li> </ul> </li> </ul> <h3>&nbsp;</h3> <h3><a href="https://www.generalproximity.bio/benefits" target="_blank"><span style="font-size: 14pt;"><strong>Benefits</strong></span></a></h3> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Top tier medical, dental, and vision coverage + One Medical membership.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">401(k) retirement plans.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Education and health/fitness incentive programs.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.&nbsp;</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Reading budget! We will buy you books. 📚</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.</span></li> </ul> <h3>&nbsp;</h3> <h3><span style="font-size: 14pt;"><strong>About Us</strong></span></h3> <p><span style="font-size: 10pt;"><strong>Work Hard/Play Hard.</strong> We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴</span></p> <p><span style="font-size: 10pt;"><strong>Strong Communication.</strong> We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.</span></p> <p><span style="font-size: 10pt;"><strong>Writing First.</strong> We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.</span></p> <p><span style="font-size: 10pt;"><strong>Growth.</strong> As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.</span></p> <hr> <p><span style="font-size: 10pt;">Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)</span></p> <p>&nbsp;</p> <p><span style="font-size: 10pt;"><strong>More info at&nbsp;<a href="https://jobs.generalproximity.bio/">jobs.generalproximity.bio</a></strong></span></p> <p>&nbsp;</p>