Structural Biology Research Scientist

Job Family: Biologist Travel Required: None Clearance Required: Ability to Obtain Public Trust What You Will Do: We are seeking a Structural Biology Research Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship. This is a full-time, on-site opportunity in Bethesda, MD. Responsibilities: Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins). Develop and optimize expression systems (mammalian, insect, or stable cell lines). Purify proteins using chromatography methods (affinity, SEC, ion exchange). Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR) Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS) Prepare samples and optimize vitrification conditions for cryo-EM studies Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios) Prepare technical reports, figures, and manuscripts What You Will Need: PhD in Structural Biology or a related field Microsoft Office Technical experience needed to assist in studying the basic principles of plant and animal life. Technical support and troubleshooting of sophisticated equipment. At least 2 (two) years of experience Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred What Would Be Nice To Have: Previous experience supporting NIH The annual salary range for this position is $85,000.00-$141,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs. What We Offer: Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace. Benefits include: Medical, Rx, Dental & Vision Insurance Personal and Family Sick Time & Company Paid Holidays Parental Leave 401(k) Retirement Plan Group Term Life and Travel Assistance Voluntary Life and AD&D Insurance Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts Transit and Parking Commuter Benefits Short-Term & Long-Term Disability Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities Employee Referral Program Corporate Sponsored Events & Community Outreach Care.com annual membership Employee Assistance Program Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.) Position may be eligible for a discretionary variable incentive bonus About Guidehouse Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation. Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco. If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation. All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. 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