Role Overview
Until is hiring a Senior Scientist, Cardiac Preservation (Organ Perfusion). This is a full-time role in Bay Area. Full responsibilities, required qualifications, and the apply link are listed in the description below.
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Job description
Until is a moonshot company building a "pause button" for biology. Our near-term focus is organ-scale reversible cryopreservation: preserving donated organs at subzero temperatures without ice formation, then rewarming them uniformly for transplant. By solving this grand challenge, we're laying the foundation for whole-body reversible cryopreservation, giving patients a bridge to future cures.
To achieve our goal, we are assembling an interdisciplinary team to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware.
We envision a future where no transplantable organ is lost to logistics, and no terminal diagnosis is final because patients can safely wait for future medicine to arrive.
About the Role
We are seeking a Senior Scientist, Cardiac Preservation to lead our heart preservation efforts within the whole organ preservation team. You will own a large domain and play a vital role in shaping how Until preserves, recovers, and assesses the viability of the heart through cryopreservation. Drawing on deep expertise in cardiac physiology and ex vivo heart perfusion, you will design and execute the experiments that make reversible cryopreservation of the heart a reality.
You will collaborate with scientists and engineers across the company on approaches grounded in the first principles of biology, physics, and chemistry. Creative and highly independent scientific engagement is a requirement of the role, and new avenues for discovery and optimization are continuously supported.
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What You'd Do:
Develop and execute ex vivo heart perfusion protocols, including normothermic machine perfusion (NMP), to maintain and evaluate cardiac viability before and after cryopreservation.
Build out the heart viability assessment toolkit, including contractile and hemodynamic function, perfusion metrics, metabolic and lactate profiling, histology, and omics.
Propose and test adjustments to cryoprotectant formulations, loading/unloading, cooling, and rewarming protocols to optimize cardiac health and recovery.
Translate detailed knowledge of cardiac physiology and biology into experimental design and interpretation across the team.
About You:
Deep, hands-on expertise in ex vivo heart perfusion, ideally including normothermic machine perfusion (NMP) of the heart.
Intimate understanding of cardiac physiology and biology, including myocardial metabolism, contractile function, and ischemia/reperfusion injury.
Experience designing and running organ viability assessments and interpreting multimodal readouts (functional, metabolic, histological, omics).
Comfort working at the bench in an ex vivo model and a track record of executing complex experimental protocols.
Demonstrated success working through hard, open-ended problems, with a passion for rapid problem solving and rapid exploration of unfamiliar topics and protocols.
Ability to think from first principles and tackle complex, cross-disciplinary problems alongside other scientists and engineers.
Preferred Qualifications
PhD in a STEM field, ideally in cardiac physiology, organ preservation, or transplant — or significant (4+ years) experience as a scientific leader in an industry context.
Direct experience with cardiac transplant or heart preservation research.
\n$175,000 - $210,000 a year\n
Benefits
Generous medical, dental and vision insurance coverage
Flexible time off and paid holidays
Competitive compensation package, including salary and equity
Access to a 401(k) retirement savings plan
FSA and commuter benefits
Daily lunch and dinners, plus a variety of snacks
Monthly learning stipend
On-site fitness center
Quarterly team social budget
About Until
Frequently Asked Questions
How do I apply for the Senior Scientist, Cardiac Preservation (Organ Perfusion) position at Until?
Use the Apply button above to submit your application directly to Until. Most applications take less than 5 minutes if your resume and contact details are ready, and you'll be routed to the employer's official application system to finish.
Where is the Senior Scientist, Cardiac Preservation (Organ Perfusion) position at Until located?
This position is based in Bay Area. Until has not indicated remote or hybrid options for this role, so candidates should plan for on-site work.
What does a Senior Scientist, Cardiac Preservation (Organ Perfusion) at Until earn?
Until has not disclosed a salary range in this posting. Many employers share specifics later in the interview process; you can also ask during a recruiter screen if compensation transparency is important to you.
When was the Senior Scientist, Cardiac Preservation (Organ Perfusion) role at Until posted?
This role was posted on May 27, 2026 (47 days ago). It's still listed as actively hiring; we re-confirm openings against the source system multiple times per day and remove closed roles.
How much experience does the Senior Scientist, Cardiac Preservation (Organ Perfusion) role at Until require?
This is a senior-level position. Most senior roles call for 5+ years of directly relevant experience. Until lists their specific requirements in the description below, so review the must-have qualifications closely before applying.
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