Skip to main content
TryApplyNow logo
Thermo Fisher Scientific logo

Principal Scientist, Large Molecule

Thermo Fisher Scientific
Full Timeprincipal
Greenfield, Indiana, USAPosted 14 days ago

Role Overview

Thermo Fisher Scientific is hiring a Principal Scientist, Large Molecule. This is a full-time role in Greenfield, Indiana. posted 2 weeks ago. Full responsibilities, required qualifications, and the apply link are listed in the description below.

Resume Keywords to Include

Make sure these keywords appear in your resume to improve ATS scoring

ORAccessibilityComplianceScheduleStandardMonFriEnvironmental

Job description

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

This is a fully onsite role based at our Greenfield, IN Laboratory. We welcome applicants from all locations within the US. We welcome applicants from all locations within the US. Please note that relocation assistance will be provided for this position, 

Must be legally authorized to work in the United States without sponsorship. 

Must be able to pass a comprehensive background check, which includes a drug screening

Discover Impactful Work:

As a Principal Scientist you will oversee the technical aspects and laboratory conduct of a significant service offering, technical area, or client program. Provide focused technical expertise as a key scientific resource for a broad array of instrument applications. Provide key technical guidance and assistance to quickly and efficiently resolve complex technical issues, for both internal support and client needs. Act as the technical project leader or subject matter expert for multiple projects or programs, interacts with clients to provide technical 
project updates, reviews and evaluates data, writes reports and protocols, and provides input on regulatory compliance. In addition, participate in the evaluation and implementation of new technologies ensuring the laboratory stays current in technologies required to best serve PPD clients and to meet business needs or explore new business growth opportunities.


What You'll Do:
• Provides assistance in the evaluation and implementation of new technologies or techniques to help move the business forward .
• Implements effective improvements in systems, processes and procedures 
increasing productivity, quality and technical expertise in the laboratory. 
• Participates in external industry organizations, including delivery of poster and 
podium presentations at conferences, or publishing in scientific journals. 
• Shares subject matter expertise with colleagues at internal PPD training events.
• Serves as a technical resource for PPD management in the assessment of client audit recommendations and SOP review.
• Serves as subject matter expert in discussions with clients and internal PPD staff to resolve scientific issues, study design and project technical requirements.
• Leads project teams conducting complex analytical studies, providing technical project management including study planning, coordination of resources, data 
evaluation, and client communication.

Education and Experience Requirements:
•Bachelor's degree (Life Sciences degree) or equivalent and relevant formal academic / vocational qualification
•Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 12+ years).


In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Knowledge, Skills, Abilities:

• Solid understanding and knowledge of general chemistry and separation science

• Demonstrated knowledge of multiple applicable techniques such as: HPLC, ELISA, GC, MS, Dissolution Testing, Inhalation Testing, Biopharmaceutical Testing, Karl Fischer, UV-Vis, FT-IR, TOC

• In-depth technical and industry knowledge in positions of technical leadership, and highly respected 
among peers for technical expertise.
• Communication / organization skills necessary to drive the implementation of technological innovation for an area or department.
• Active participant in industry discussion groups / technology conferences and presenting at industry events and conferences.
• Knowledge of regulatory agency audits from a technological standpoint and perspective.
• Proven ability to implement process improvement and technological advancement at the group or 
department level.

Working Conditions and Environment:

Thermo Fisher Scientific values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:

  • Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.

  • Able to work upright and stationary and/or standing for typical working hours.

  • Able to lift and move objects up to 25 pounds.

  • Able to work in non-traditional work environments.

  • Able to use and learn standard office equipment and technology with proficiency.

  • May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.

  • Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.


Why Join Us?
When you join Thermo Fisher Scientific, you become part of a global team that values passion, innovation, and a commitment to scientific excellence. You’ll work in an environment where collaboration and development are part of the everyday experience—and where your contributions truly make a difference.

Apply today to help us deliver tomorrow’s breakthroughs.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

Accessibility/Disability Access

Job Seekers with a Disability: Thermo Fisher Scientific offers accessibility service for job seekers requiring accommodations in the job application process. For example, this may include individuals requiring assistance because of hearing, vision, mobility, or cognitive impairments. If you are a job seeker with a disability, or assisting a person with a disability, and require accessibility assistance or an accommodation to apply for one of our jobs, please submit a request by telephone at 1-855-471-2255*. Please include your contact information and specific details about your required accommodation to support you during the job application process.

This telephone line is reserved solely for job seekers with disabilities requiring accessibility assistance or an accommodation in the job application process. Messages left for other purposes, such as not being able to get into the career website, following up on an application, or other non-disability related technical issues will not receive a response.

About Thermo Fisher Scientific

Thermo Fisher Scientific logo

Thermo Fisher Scientific

thermofisher.com

On-site

224 other open roles at Thermo Fisher Scientific on TryApplyNow.

Frequently Asked Questions

How do I apply for the Principal Scientist, Large Molecule position at Thermo Fisher Scientific?

Use the Apply button above to submit your application directly to Thermo Fisher Scientific. Most applications take less than 5 minutes if your resume and contact details are ready, and you'll be routed to the employer's official application system to finish.

Where is the Principal Scientist, Large Molecule position at Thermo Fisher Scientific located?

This position is based in Greenfield, Indiana. Thermo Fisher Scientific has not indicated remote or hybrid options for this role, so candidates should plan for on-site work.

What does a Principal Scientist, Large Molecule at Thermo Fisher Scientific earn?

Thermo Fisher Scientific has not disclosed a salary range in this posting. Many employers share specifics later in the interview process; you can also ask during a recruiter screen if compensation transparency is important to you.

When was the Principal Scientist, Large Molecule role at Thermo Fisher Scientific posted?

This role was posted on July 7, 2026 (14 days ago). It's still listed as actively hiring; we re-confirm openings against the source system multiple times per day and remove closed roles.

AI-powered job search

Get every job scored to your resume

Upload your resume and get jobs ranked, your resume tailored, and employee contacts found automatically.

Get started free

No credit card to start