Role Overview
Profluent is hiring a Machine Learning Scientist, BioML. This is a full-time hybrid role, based in Emeryville, California, United States; Hybrid (2-3 days on-site). posted 2 weeks ago. Full responsibilities, required qualifications, and the apply link are listed in the description below.
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Job description
Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.
We're looking for a motivated and creative Machine Learning (ML) Scientist to drive research into models at the intersection of complex protein biology and AI. This position offers an opportunity to work at the forefront of generative modeling research across language processing, representation learning, and protein engineering. You should be a self-directed researcher who has the ability to rapidly prototype and evaluate new models and algorithms in the biomolecular domain.
As an early employee, you will proactively shape the direction of our machine learning efforts and collaborate across diverse teams of computational and experimental scientists.
Responsibilities
- Design and develop state-of-the-art predictive and generative models incorporating domain-specific evolutionary and experimental data
- Leverage massive-scale protein and nucleic acid data to train specialized models for protein understanding and design
- Curate relevant datasets and design tasks for rigorous evaluation of generative models
- Collaborate across the machine learning and protein design teams to adapt and apply techniques for experimental validation
- Implement, analyze, and interpret multiple computational approaches and present results to colleagues in regular update meetings
- Work within a collaborative, fast-paced, interdisciplinary team across biology and machine learning to help shape the scientific and strategic vision of the company
Qualifications
- PhD (or equivalent industry experience) in Computer Science, Machine Learning, Natural Language Processing, Applied Math, Computational Biology, Statistics, or a related field
- Experience with conceiving of, implementing, and evaluating novel machine learning techniques at the intersection with biology
- Publications at major machine learning conferences (NeurIPS, ICML, ICLR) or scientific journals (Nature, Science, Nature Biotech, Nature Methods, PNAS)
- Experience with modern deep learning frameworks such as Pytorch or Jax
Preferences
- Familiarity with foundational biology of proteins and nucleic acids
- Experience developing machine learning models for proteins (language models, structure prediction, design)
- Experience with cloud compute platforms (GCP, AWS, Azure, OCI)
- Previous experience in data extraction and curation from bioinformatics data sources
- Familiarity with wet lab experimental assays and associated limitations
- 3 to 5 years of industry experience
What We Offer
- High-growth opportunity with meaningful impact on the future of protein design
- Competitive compensation package with equity participation
- 401(k) with a strong employer match
- Comprehensive benefits including health/dental/vision insurance
- Generous PTO policy and commitment to work-life balance
- Professional development opportunities in a cutting-edge field at the intersection of AI and biology
Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.
Employment Eligibility Verification
Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.
About Profluent
Frequently Asked Questions
How do I apply for the Machine Learning Scientist, BioML position at Profluent?
Use the Apply button above to submit your application directly to Profluent. Most applications take less than 5 minutes if your resume and contact details are ready, and you'll be routed to the employer's official application system to finish.
Is the Machine Learning Scientist, BioML role at Profluent remote or in-office?
This is a hybrid role based in Emeryville, California, United States; Hybrid (2-3 days on-site). Expect a mix of in-office and remote days, with the specific cadence set by the hiring manager.
What does a Machine Learning Scientist, BioML at Profluent earn?
Profluent has not disclosed a salary range in this posting. Many employers share specifics later in the interview process; you can also ask during a recruiter screen if compensation transparency is important to you.
When was the Machine Learning Scientist, BioML role at Profluent posted?
This role was posted on June 22, 2026 (17 days ago). It's still listed as actively hiring; we re-confirm openings against the source system multiple times per day and remove closed roles.
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