Scientist, In Vivo CAR-T Pipeline

Full Timesenior

Philadelphia, PAPosted 14 days ago

Role Overview

Legendcareers is hiring a senior-level Scientist, In Vivo CAR-T Pipeline. This is a full-time role in Philadelphia. posted 2 weeks ago. Full responsibilities, required qualifications, and the apply link are listed in the description below.

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Job description

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Scientist, In Vivo CAR-T Pipeline as part of the Research and Development team based in Philadelphia, PA.

Role Overview

Legend Biotech is a global leader in the development of innovative cell-based therapies. We are seeking a highly motivated Scientist to join our growing in vivo CAR-T development team. This role provides the opportunity to make a direct scientific impact by advancing our in vivo CAR-T platform from early discovery through preclinical development.

The successful candidate will bring deep technical expertise in cell&gene therapy, along with a strong foundation in immunology and virology. You will work in a highly collaborative environment alongside research and early development teams to translate novel scientific concepts into robust therapeutic candidates. This role requires scientific rigor, hands-on execution, intellectual curiosity, and the ability to thrive in a fast-paced research setting.

This is a fully onsite, lab-based position located in Philadelphia, PA.

Key Responsibilities

Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs.
Conduct and analyze in vitro and in vivo studies to assess product potency, efficacy, and safety.
Develop, optimize, and troubleshoot experimental assays, including:
- Cell line engineering
- Cell-based functional and cytotoxicity assays
- ELISA and PCR-based assays
- High-throughput binder screening
- Viral vector packaging and titration
- Analyze and interpret complex datasets and maintain accurate experimental documentation.
- Prepare clear, high-quality reports and presentations and communicate findings to internal research and cross-functional teams.

Requirements

PhD in Immunology, Cell Biology, Molecular
OR Master’s degree with 3–6+ years of relevant experience
Hands-on experience in immunology, cell therapy, gene therapy, or related fields
Experience with viral vector systems (especially lentivirus) is highly preferred
Industry or postdoctoral experience is a plus

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy notice, please review: Legend Biotech Privacy Notice.

About Legendcareers

Legendcareers

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Frequently Asked Questions

How do I apply for the Scientist, In Vivo CAR-T Pipeline position at Legendcareers?

Use the Apply button above to submit your application directly to Legendcareers. Most applications take less than 5 minutes if your resume and contact details are ready, and you'll be routed to the employer's official application system to finish.

Where is the Scientist, In Vivo CAR-T Pipeline position at Legendcareers located?

This position is based in Philadelphia. Legendcareers has not indicated remote or hybrid options for this role, so candidates should plan for on-site work.

What does a Scientist, In Vivo CAR-T Pipeline at Legendcareers earn?

Legendcareers has not disclosed a salary range in this posting. Many employers share specifics later in the interview process; you can also ask during a recruiter screen if compensation transparency is important to you.

When was the Scientist, In Vivo CAR-T Pipeline role at Legendcareers posted?

This role was posted on June 26, 2026 (14 days ago). It's still listed as actively hiring; we re-confirm openings against the source system multiple times per day and remove closed roles.

How much experience does the Scientist, In Vivo CAR-T Pipeline role at Legendcareers require?

This is a senior-level position. Most senior roles call for 5+ years of directly relevant experience. Legendcareers lists their specific requirements in the description below, so review the must-have qualifications closely before applying.