Role Overview
Genentech is hiring a Principal Healthcare Compliance Manager, Healthcare Compliance Office (HCO). This is a full-time role in South San Francisco. Part of Genentech's Risk hiring. The posted range is $177k to $328k. Full responsibilities, required qualifications, and the apply link are listed in the description below.
Salary Context
This role offers $177k-$328k. The median for Principal-level Risk roles is $150k-$205k (based on 32 listings). 42% above median.
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Job description
Join Genentech in South San Francisco, CA as a Principal Healthcare Compliance Manager, Advisory!
Seeking a highly experienced senior compliance professional for a strategic role with significant organizational impact. As a Principal Healthcare Compliance Advisor, you will serve as the primary consultant for multiple business units, advising on and developing policy, guidelines, and training for complex risk areas.
This role holds full strategic responsibility for understanding business priorities and advising across the compliance ecosystem. You will proactively research evolving regulations, influence the development of long-range plans and overall objectives for Genentech, and represent the department on high-impact cross-functional committees. Decisions in this role have a significant impact. You will lead or participate in complex projects and challenge the status quo to address difficult problems.
The Opportunity
Key responsibilities of this role includes the following:
Acting as a primary consultant and point-of-contact for compliance questions
Developing relationships and providing guidance across function
Maintaining expertise in healthcare compliance legislation and industry practices
Advising Roche global partners on US changes and Genentech's strategy
Leading or participating in large, complex cross-functional projects
Who You Are:
7 or more years of work experience with JD (including 5+ direct experience) ; OR
12 or more years of work experience (including 10+ direct experience) in a legal or corporate compliance group in the bio/pharma/DIA industry advising/leading project teams in design, development and implementation of elements of a corporate compliance program or projects with significant organizational impact
If you possess strong compliance acumen, leadership skills, and the ability to influence outcomes while maintaining impeccable ethics, apply today!
#HealthcareCompliance #PharmaCompliance #ComplianceJobs #Genentech #BiotechJobs #PrincipalManager #SouthSanFrancisco #SSF
This role is located onsite at Genentech’s South San Francisco, California campus.
Relocation benefits are not available for this position.
The expected salary range for this position based on the primary location of California is $176,500 to $327,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
About Genentech

Genentech
gene.com
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Frequently Asked Questions
How do I apply for the Principal Healthcare Compliance Manager, Healthcare Compliance Office (HCO) position at Genentech?
Use the Apply button above to submit your application directly to Genentech. Most applications take less than 5 minutes if your resume and contact details are ready, and you'll be routed to the employer's official application system to finish.
Where is the Principal Healthcare Compliance Manager, Healthcare Compliance Office (HCO) position at Genentech located?
This position is based in South San Francisco. Genentech has not indicated remote or hybrid options for this role, so candidates should plan for on-site work.
How much does the Principal Healthcare Compliance Manager, Healthcare Compliance Office (HCO) role at Genentech pay?
Genentech has posted a compensation range of $177k to $328k for this position. Final offers typically vary based on candidate experience, location, and internal salary bands.
When was the Principal Healthcare Compliance Manager, Healthcare Compliance Office (HCO) role at Genentech posted?
This role was posted on June 11, 2026 (42 days ago). It's still listed as actively hiring; we re-confirm openings against the source system multiple times per day and remove closed roles.
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