Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking an Research & Development Intern as part of the Novel Car Design team based in Somerset, NJ.

Role Overview

This internship will focus on advancing our assessment of in vivo CAR T cell platform. This role will provide hands-on experience in preclinical research and adoptive cell therapy, providing the intern with the opportunity to contribute to cutting-edge experiments and data analysis that drive innovation in our research program.

Key Responsibilities

• Assist in the execution of laboratory experiments, including mammalian cell culture, virus preparation, and immunological and biochemical assays.
• Perform transfections for virus production and assess viral titers using flow cytometry–based and ELISA-based assays.
• Conduct PBMC transduction and perform immunoassays to screen and validate candidates with improved efficacy and safety profiles.
• Perform cytotoxicity assays, immunophenotyping, and cytokine analyses.
• Maintain accurate and detailed records of experimental procedures, data, and observations in laboratory notebooks.
• Analyze experimental data and prepare summaries and reports for team discussions.
• Collaborate with senior scientists and team members to troubleshoot, optimize, and refine experimental protocols.
• Candidate is encouraged to provide technical approaches and troubleshooting strategies, but all experimental plans, data interpretation, and project-related decisions require review and approval by the manager or designated mentor.
• Decisions regarding project scope, timelines, resource allocation, and overall strategic direction remain under management oversight and are aligned with overall business pipeline priorities.

Requirements

• Currently enrolled in, or recently graduated from, a Bachelor’s, Master’s program in Biology, Biotechnology, Biochemistry, Immunology, or a related field.
• Preferred to have basic laboratory skills with some hands-on experience in mammalian cell culture (immune cells) and other standard molecular biology techniques, including flow cytometry, qPCR/ddPCR, ELISA, and immunoassays. The ideal candidate would also have some cellular therapy experience.
• Strong analytical and problem-solving, and organizational abilities.
• Excellent written and verbal communication skills.
• Works well independently while thriving in a collaborative team environment.
• Prefer the candidate to have some knowledge of data analysis tools such as Microsoft Office (Excel, Powerpoint), Graphpad Prism, and potentially R and Python.

Benefits

Benefits include medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Please note: These benefits are offered exclusively to permanent full-time employees. Contract employees are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

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