Overview

KisoJi Biotech is advancing next‑generation antibody therapeutics through the integration of proprietary transgenic heavy chain‑only antibody (HCAb) platforms, AI‑guided discovery, functional screening technologies, and high‑throughput single‑cell screening systems.

Position

Senior Research Associate – Site: Toronto, Ontario; Department: Assay Development

Responsibilities

• Plan and execute single B cell and plasma cell screening workflows following animal immunization campaigns.
• Operate and optimize the CellCelector platform for single‑cell isolation, imaging, clone recovery, and antibody discovery applications.
• Develop and execute screening assays for antigen binding and cell‑based functional activity.
• Support the implementation and optimization of droplet microfluidics‑based screening technologies for high‑throughput functional antibody discovery.
• Perform mammalian cell culture and support functional screening workflows using reporter assays, flow cytometry, imaging systems, and cell‑based assays.
• Troubleshoot methods, improve workflows, and contribute to the development of new antibody discovery technologies.
• Maintain accurate experimental records and clearly communicate results through reports, presentations, and team discussions.
• Assist in SOP development, workflow standardization, and laboratory organization.
• Collaborate closely with multidisciplinary teams across discovery, assay development, computational biology, and protein engineering.
• Participate in project planning, prioritization, and technology evaluation discussions.

Essential Qualifications

• M.Sc. in Immunology, Cell Biology, Molecular Biology, Biotechnology, Bioengineering, or a related field with at least 5–7 years of industry experience.
• Minimum 3 years of hands‑on experience in antibody discovery or single‑cell screening workflows.
• Experience with mammalian cell culture and cell‑based functional assays.
• Experience operating advanced screening or cell handling instrumentation such as CellCelector, FACS/flow cytometry systems, high‑content imaging platforms, or microfluidics systems.
• Experience with one or more of the following: single B cell screening, functional antibody screening, microfluidics workflows, mammalian display, reporter‑based functional assays.
• Robust troubleshooting and problem‑solving skills with the ability to independently optimize assays and workflows.
• Excellent organizational skills, attention to detail, and strong verbal and written communication skills.
• Ability to work independently while effectively collaborating within cross‑functional teams.
• Legally authorized to work in Canada.

Assets

• Experience with droplet microfluidics systems for single‑cell or functional screening.
• Experience with flow cytometry assay development and cell sorting.
• Experience with reporter assays, imaging‑based screening, or phenotypic screening.
• Familiarity with automation and high‑throughput screening systems.
• Experience in oncology or GPCR‑focused therapeutic discovery programs.

Benefits Package Includes

• Health and dental insurance plans.
• Paid vacation and holidays.

Incentive Programs Include

• Training and development programs/courses.
• Annual performance reviews with yearly bonuses.
• Opportunity to work with cutting‑edge antibody discovery technologies.
• Exposure to advanced AI‑guided therapeutic discovery platforms.

Salary

The salary range for this position is $80,000–120,000 CAD, depending on experience, technical expertise, and qualifications. Compensation will take into account internal equity, work location, and relevant industry experience.

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