Chief of Staff
Acumen Pharmaceuticals, Inc. - Common StockJob Description
Acumen is seeking an experienced Chief of Staff to serve as a strategic advisor and execution partner to our Founder & CEO, working in close partnership with the President & Chief Investment Officer. This role requires a highly strategic operator with strong judgment, exceptional communication skills, and demonstrated experience translating complex ideas into clear priorities and coordinated action. The Chief of Staff will support executive decision-making, drive cross-organizational initiatives, steward critical relationships, and ensure alignment across external engagements. This role is based in New York City and operates in a hybrid model, with three days in the office per week (Tuesday, Wednesday, Thursday), and some global travel.
About Acumen
Acumen is a global force of entrepreneurs, investors, philanthropists, and social innovators working together to build a world based on dignity. We were founded by Jacqueline Novogratz on the radical idea that business, when cultivated with moral imagination, can break the cycle of poverty. We invest in transformational companies, build sustainable markets, and prepare leaders with the tools they need to create a more just and inclusive future. Since 2001, we have scaled companies and shaped markets in some of the hardest-to-reach communities on the planet, impacting over half-a-billion lives. To learn more visit acumen.org.
About the role
The Chief of Staff to the CEO is a senior, trusted advisor and execution partner to Acumen’s Founder & CEO. This role operates at the center of Acumen’s leadership, strategy, and institutional priorities, enabling the CEO to operate at maximum effectiveness internally and externally.
The Chief of Staff functions as an extension of the CEO—providing strategic counsel, translating vision into execution, managing complex cross-organizational initiatives, and stewarding critical internal and external relationships. The role requires exceptional judgment, discretion, intellectual rigor, and the ability to operate seamlessly across strategy, operations, communications, and influence.
Key Responsibilities
Strategic Partnership & Executive Support
- Serve as a thought partner to the CEO on institutional strategy, priorities, and long-term positioning.
- Translate Acumen’s strategic direction into clear, actionable priorities across teams and leaders.
- Shape where and how the CEO shows up so as to enhance her effectiveness as a leading voice for reimagining philanthropy, finance and entrepreneurship to solve problems of poverty and climate at scale.
- Synthesize complex information, surface trade-offs, and drive high-quality executive decision-making.
- Act as a proxy for the CEO in select meetings and engagements, representing her voice, intent, and values.
- External Engagement, Communications & Influence
- Coordinate the CEO’s external presence across key moments and platforms, including UNGA, COP, Davos, and other high-level convenings.
- Partner with the Communications team to steward and refine the CEO’s voice internally and externally.
- Prepare strategic briefings, talking points, and context for engagements with donors, investors, policymakers, and peer leaders.
- Ensure alignment between Acumen’s strategy, values, and public narrative.
- Support relationship strategy and follow-up for priority external stakeholders.
Office of the CEO Leadership & Coordination
- Lead the day-to-day functioning of the Office of the CEO, ensuring clarity of roles, cadence, and execution across priorities.
- Coordinate closely with the President/Chief Investment Officer, and senior leadership to ensure alignment and follow-through on organizational goals.
Institutional Strategy & Special Initiatives
- Drive high-priority, cross-cutting initiatives on behalf of the CEO, including institutional strategy shifts, major partnerships, governance transitions, and flagship programs.
- Own planning and execution for complex, multi-stakeholder projects that span regions, funds, and functions.
- Track progress against CEO and organizational goals, flag risks, and unblock issues as needed.
<
More Jobs at Acumen Pharmaceuticals, Inc. - Common Stock
View all →Short Term Program Associate, Acumen Academy Pakistan
Acumen Pharmaceuticals, Inc. - Common Stock
Program Legal Counsel
Acumen Pharmaceuticals, Inc. - Common Stock
Manager, Government Partnerships
Acumen Pharmaceuticals, Inc. - Common Stock
Legal Counsel
Acumen Pharmaceuticals, Inc. - Common Stock
Communications Senior Associate, Social and Content
Acumen Pharmaceuticals, Inc. - Common Stock
Want AI-powered job matching?
Upload your resume and get every job scored, your resume tailored, and hiring manager emails found - automatically.
Get Started Free